Oyster Pond River, also called Oyster Creek, is a 1.7-mile-long (2.7 km) river in Chatham, Massachusetts on Cape Cod.
The river is an estuary connecting Oyster Pond with Stage Harbor, averaging 3 to 5 feet (1 to 2 m) in depth and bordered with salt marshes. Both river and pond provide excellent anchorage. According to an assessment for the Massachusetts Estuaries Project, its total surface area is 88.1 acres (357,000 m2).